External citations are calculated by subtracting the number of self-citations from the total number of citations received by the journal’s documents. Authors may transfer research manuscripts from the preprint servers bioRxiv and medRxiv for submission to the JCI. Larger randomized controlled trials are needed to further assess the safety and efficacy of ruxolitinib in the treatment of AA.
Immunofluorescence confocal microscopy identified the disruption of alveolar structure and loss of the normal proximal-peripheral differentiation of pulmonary epithelial cells. Journal of Clinical Investigation; JCI Insight; Main Menu.
JCI Insight’s 2018 Impact Factor, the first for the journal, is 6.014. These results indicate that ferroptosis contributes to neuronal death after ICH, that administration of ferrostatin-1 protects hemorrhagic brain, and that cyclooxygenase-2 could be a biomarker of ferroptosis. An account is required in order to proceed with submission; authors can register for accounts or access their existing accounts by following the instructions at the-jci.org.. In the case of academic evaluation for tenure, it is sometimes inappropriate to use the impact of the source journal to estimate the expected frequency of a recently published article. The findings recapitulate those of previous studies of common cancers but also identify alterations, including in AXL and EGFR, associated with response to targeted therapies. 73% of patients harbored an actionable or informative alteration; only 19% of these represented a current standard of care for therapeutic stratification. It is based on the idea that 'all citations are not created equal'. 学術雑誌合格-拒絶 率、 The SJR is a size-independent prestige indicator that ranks journals by their 'average prestige per article'. The chart shows the evolution of the average number of times documents published in a journal in the past two, three and four years have been cited in the current year.
11.08% Journal Impact Trend Forecasting System displays the exact … CONCLUSION. The JCI reaches readers across a wide range of medical disciplines and sectors.
Clinical implementation of tumor profiling in an enterprise-wide, unselected cancer patient population has yet to be reported. New England Journal of Medicine, ISSN: 0021-9738. Transcriptomic analysis of normal human lung epithelial cells defined gene expression patterns associated with highly differentiated alveolar type 2 (AT2) cells, indicated by enrichment of RNAs critical for surfactant homeostasis. Results were categorized by pathologists based on actionability. Evolution of the number of total citation per document and external citation per document (i.e.
Lynette M. Sholl, Khanh Do, Priyanka Shivdasani, Ethan Cerami, Adrian M. Dubuc, Frank C. Kuo, Elizabeth P. Garcia, Yonghui Jia, Phani Davineni, Ryan P. Abo, Trevor J. Pugh, Paul van Hummelen, Aaron R. Thorner, Matthew Ducar, Alice H. Berger, Mizuki Nishino, Katherine A. Janeway, Alanna Church, Marian Harris, Lauren L. Ritterhouse, Joshua D. Campbell, Vanesa Rojas-Rudilla, Azra H. Ligon, Shakti Ramkissoon, James M. Cleary, Ursula Matulonis, Geoffrey R. Oxnard, Richard Chao, Vanessa Tassell, James Christensen, William C. Hahn, Philip W. Kantoff, David J. Kwiatkowski, Bruce E. Johnson, Matthew Meyerson, Levi A. Garraway, Geoffrey I. Shapiro, Barrett J. Rollins, Neal I. Lindeman, Laura E. MacConaill. FUNDING. C=対象の雑誌が2017年,2018年に掲載した論文が、2019年に引用された延べ回数; 25% scientists expect Journal of Clinical Investigation Journal Impact 2019-20 will be in the range of 14.5 ~ 15.0.
These results demonstrate that prolonged telomere dysfunction in type II AECs, but not collagen-expressing cells, leads to age-dependent lung remodeling and fibrosis. The Journal of Clinical Investigation has a respected history as a vital publication for the physician and scientist alike. インパクトファクター は、自然科学・社会科学分野の学術雑誌を対象として、その雑誌の影響度、引用された頻度を測る指標である。インパクトファクター特定の年の平均引用数は、最初の2年間に発表された論文の総数から計算されました。たとえばある雑誌の2019年のインパクトファクターは2017年と2018年の論文数、2019年のその雑誌の被引用回数から次のように求める。 The present study provides a rich data source to further explore lung health and disease. FUNDING. JCI Insight’s 2018 Impact Factor, the first for the journal, is 6.014. The set of journals have been ranked according to their SJR and divided into four equal groups, four quartiles. Intracerebral hemorrhage (ICH) causes high mortality and morbidity, but our knowledge of post-ICH neuronal death and related mechanisms is limited. METHODS.
Safety parameters remained largely within normal limits, and no serious adverse effects were reported.
We report the results for the first 3,727 patients tested. more. Medicine (miscellaneous) (Q1)。, Journal of Clinical Investigation - 重要な指標, 実際、単一の指標のみを使用してJournal of Clinical Investigationジャーナルの影響を完全に理解することは困難であるため、貢献への参照を提供するにはより多くの指標が必要です。学術アクセラレーターは、学術雑誌略称 ISO4、 Deletion of TRF1 in type II AECs for up to 9 months resulted in short telomeres and lung remodeling characterized by increased numbers of type II AECs, α-smooth muscle actin+ mesenchymal cells, collagen deposition, and accumulation of senescence-associated β-galactosidase+ lung epithelial cells. BACKGROUND. Self-Citation Ratio、 Journal impact search engine. Nine of twelve patients (75%) demonstrated a remarkable response to treatment, with average hair regrowth of 92% at the end of treatment. Journal of Clinical Investigation 2019-20年の最新のインパクトファクターパーティション： Additionally, we found that ferrostatin-1 reduced lipid reactive oxygen species production and attenuated the increased expression level of PTGS2 and its gene product cyclooxygenase-2 ex vivo and in vivo. In rare cancers, potentially actionable alterations suggest the utility of a “cancer-agnostic” approach in genomic profiling. In addition to the 2-year Journal Impact, the 3年インパクトファクター can provide further insights into the impact of Journal of Clinical Investigation.
The insights gained from this study will advance our knowledge of the post-ICH cell death cascade and be essential for future preclinical studies. SJR is a measure of scientific influence of journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from Journal Impact Trend Forecasting System provides an open, transparent, and straightforward platform to help academic researchers Predict future journal impact and performance through the wisdom of crowds. Email(will not be published) scRNA-seq analyses identified loss of normal epithelial cell identities and unique contributions of epithelial cells to the pathogenesis of IPF. Developments in the clinical research lead to novel diagnostic procedures, drug design and development and innovative delivery mechanism. TRIAL REGISTRATION.
Broad sequencing-based testing deployed across an unselected cancer cohort is feasible. BACKGROUND.
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Pathway analysis predicted aberrant activation of canonical signaling via TGF-β, HIPPO/YAP, P53, WNT, and AKT/PI3K. B=対象の雑誌が2018年に掲載した論文数; Journal Impact Trend Forecasting System displays the exact community-driven Data without secret algorithms, hidden factors, or systematic delay.
Locks of Love Foundation, the Alopecia Areata Initiative, NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the Irving Institute for Clinical and Translational Research/Columbia University Medical Center Clinical and Translational Science Award (CUMC CTSA). The users of Scimago Journal & Country Rank have the possibility to dialogue through comments linked to a specific journal. We conclude that telomere dysfunction in type II AECs is sufficient to cause lung fibrosis, and may be a dominant molecular defect causing IPF. Telomeres are short in type II alveolar epithelial cells (AECs) of patients with idiopathic pulmonary fibrosis (IPF). Journal Impact Trend Forecasting System provides an open, transparent, and straightforward platform to help academic researchers Predict future journal impact and performance through the wisdom of crowds. Evolution of the total number of citations and journal's self-citations received by a journal's published documents during the three previous years. In this pilot study, 9 of 12 patients (75%) treated with ruxolitinib showed significant scalp hair regrowth and improvement of AA. . This indicator counts the number of citations received by documents from a journal and divides them by the total number of documents published in that journal. Manuscript submission [Back to top] Manuscripts must be submitted through the JCI’s submission website. Qian Li, Xiaoning Han, Xi Lan, Yufeng Gao, Jieru Wan, Frederick Durham, Tian Cheng, Jie Yang, Zhongyu Wang, Chao Jiang, Mingyao Ying, Raymond C. Koehler, Brent R. Stockwell, Jian Wang. SPC-Cre TRF1fl/fl mice will be useful for assessing cellular and molecular mechanisms of lung fibrosis mediated by telomere dysfunction. 学術雑誌人気のリサーチおよび 25% scientists expect Journal of Clinical Investigation Journal Impact 2019-20 will be in the range of 14.5 ~ 15.0.
Compared with historical Journal Impact data, the Journal Impact 2018 of Journal of Clinical Investigation dropped by Journal of Clinical Investigation - インパクトファクタートレンド予測システム, 学術研究者の 25% は、Journal of Clinical Investigation 2019-20のインパクトファクターが14.5 ~ 15.0の範囲になると予測しています。
Here, we investigated the use of the oral JAK1/2 inhibitor ruxolitinib in the treatment of patients with moderate-to-severe AA. Deletion of TRF1 in collagen-expressing cells caused pulmonary edema, but not fibrosis. For topics on particular articles, maintain the dialogue through the usual channels with your editor. Retrospective analyses uncovered contextual genomic features that may inform therapeutic response and examples where diagnoses revised by genomic profiling markedly changed clinical management. (United States) です，
In contrast, scRNA-seq of IPF cells identified 3 distinct subsets of epithelial cell types with characteristics of conducting airway basal and goblet cells and an additional atypical transitional cell that contributes to pathological processes in IPF.
Whether dysfunctional telomeres contribute directly to development of lung fibrosis remains unknown. RESULTS.
Several highly cited articles that contributed to the Impact Factor are listed below. Ram P. Naikawadi, Supparerk Disayabutr, Benat Mallavia, Matthew L. Donne, Gary Green, Janet L. La, Jason R. Rock, Mark R. Looney, Paul J. Wolters, Lynette M. Sholl, … , Neal I. Lindeman, Laura E. MacConaill, Yan Xu, … , Barry R. Stripp, Jeffrey A. Whitsett, Julian Mackay-Wiggan, … , Angela M. Christiano, Raphael Clynes, Qian Li, … , Brent R. Stockwell, Jian Wang, Ram P. Naikawadi, … , Mark R. Looney, Paul J. Wolters, Published June 23, 2019, by JCI Insight staff, Published March 16, 2017; First published December 8, 2016, Institutional implementation of clinical tumor profiling on an unselected cancer population, https://doi.org/10.1172/jci.insight.87062, Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis, https://doi.org/10.1172/jci.insight.90558, Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata, https://doi.org/10.1172/jci.insight.89790, Inhibition of neuronal ferroptosis protects hemorrhagic brain, https://doi.org/10.1172/jci.insight.90777, Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis, https://doi.org/10.1172/jci.insight.86704, American Society for Clinical Investigation. Yan Xu, Takako Mizuno, Anusha Sridharan, Yina Du, Minzhe Guo, Jie Tang, Kathryn A. Wikenheiser-Brokamp, Anne-Karina T. Perl, Vincent A. Funari, Jason J. Gokey, Barry R. Stripp, Jeffrey A. Whitsett.
RESULTS.
H-Index、 Journal of Clinical Investigationの研究領域には、これらのカテゴリが含まれます:
Several highly cited articles that contributed to the Impact Factor are listed below. Mice treated with ferrostatin-1 after ICH exhibited marked brain protection and improved neurologic function.